QCRG Developmental Research Project Awardee

Project: "Targeting SARS-CoV-2 Orf9b for Antiviral Therapies"

Q1. What is your project focused on?

• Our project focuses on developing small molecule inhibitors that target one of the critical proteins of SARS-CoV-2 virus (called Orf9b) which is involved in viral modulation of the immune system. Blocking Orf9b function has the potential to not only fight off virus infection but also relieve some of the severe symptoms associated with the disease.

Q2. How does your project align with the Center’s objectives?

• This project aims to develop effective inhibitors against SARS-CoV-2 viral target using an innovative drug screening approach. This will allow us to continue and accelerate pioneering efforts in expanding the repertoire of current therapeutic approaches and limiting the spread of the global pandemic, which completely aligns with the Center’s objectives.

Q3. What is the most inspiring aspect about your project/research focus?

• All the key discoveries we will make in our project have the potential to unlock new ways to combat the spread of SARS-CoV-2 infection and help ease the global burden of coronavirus disease as well as to quickly pivot to address future viral outbreaks or pandemics.

Q4. Do you think collaboration is important for the progression of your research? If so, why are you interested in connecting with members of the QCRG?

• We will work in close collaboration with multiple members of the QCRG AViDD program and this collaboration is critical for the advancement of the project. Working in alliance with QCRG members will accelerate the accomplishment of the Center’s ultimate goal of discovering antivirals by utilizing their diverse scientific skills.

Q5. What are your thoughts on the importance of building pandemic preparedness?

• The possibility of any pandemic outbreak arising in the future poses an evident major and immediate threat to human life across the globe. Building pandemic preparedness is vital to respond effectively to potential outbreaks of either known or novel pathogens and therefore, to prevent future global health crises.