University of California San Francisco

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    • Home
    • QCRG
      • QCRG Overview
      • Team
      • QCRG SBC
      • Publications
      • Press
      • Interactive COVID-19 Map
      • Partners
      • Learn more about QBI
    • QCRG AViDD
      • QCRG AViDD Overview
      • Investigators
      • Projects
      • Cores
    • Jobs
    • Opportunities
    • Contact us
QCRG
  • Home
  • QCRG
    • QCRG Overview
    • Team
    • QCRG SBC
    • Publications
    • Press
    • Interactive COVID-19 Map
    • Partners
    • Learn more about QBI
  • QCRG AViDD
    • QCRG AViDD Overview
    • Investigators
    • Projects
    • Cores
  • Jobs
  • Opportunities
  • Contact us

QCRG AVIDD PROGRAM

CORES

We aim to advance targets and compounds for antiviral drug discovery. The team has expertise in drug discovery from target identification and characterization to Lead Optimization. Using the QCRG Drug Discovery Platform, each of the six Projects will be supported by eight Cores. 


Overall, we will follow the traditional, interactive workflow of drug discovery, but each Project and Core includes innovative facets that reflect the unique specialties of the investigators. The 5-year program will deliver 3–6 Optimized Lead molecules to
 Roche and potentially other partners for preclinical and clinical 
development. Graduation from each stage of the drug discovery
 process will follow design criteria that align with pharmaceutical
 company standards and will be informed by our Target Product
 Profile for an oral antiviral agent
.

Lead: Stroud; Co-I: Kortemme, Fraser

Lead: Arkin; Co-I:Shoichet, Fraser, Gestwicki

Lead: Renslo; Co-I: Shoichet, Jin

Lead: Agard; Co-I: Verba, Cheng, Stroud, Fraser

Lead: Sali; Co-I: Echeverria, Beltrao, Keiser, Kortemme

Lead: Ott; Co-I: Garcia-Sastre, Towers, Jolly, Vignuzzi, Sesma, Saleh, Martinez, Zuliani-Alvarez, Doudna

Lead: Garcia-Sastre; Co-I: White, Albrecht, Vignuzzi, Saleh, Ott

Lead: Swaney; Co-I: Kaake, Krogan

Lead: Krogan; Co-I: Zuliani-Alvarez, Eckhardt

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